Global Advancement of
Head and Neck Surgery and Cancer Research

“The measure of a society is found in how they treat their weakest and most helpless citizens.”
 — Jimmy Carter —
We acknowledge the invaluable support by Dr. Sybill Storz and the company KARL STORZ as well as the American Head and Neck Society and the many Trusts having donated to us.

CORE THEMES

Betel nut-induced Oral Cancer

Betel nut is a substance chewed by 10% of the global population and is known to cause mouth cancer, playing an especially significant role in South and South-East Asian countries as well as in migrant groups in the UK and the US. The BICRAA application was previously developed as an innovative data collection tool, which we used to obtain data in the Maharashtra and Delhi regions in India, which showed us that there is a high incidence of betel nut use and a general lack of awareness regarding its carcinogenic potential. As such, we have developed the Beat Betel campaign, which is a two-fold initiative with the ultimate goal of improving public health awareness and decreasing mouth cancer rates, globally. 

Firstly, we are planning a large-scale cross-sectional survey with the aim of understanding betel nut awareness on a global scale, results of which will inform governmental and non-governmental organizations in order to bring this prominent issue into the fore and develop strategies to mitigate its use. The second component of our work is to develop an early detection molecular test. Mouth cancer mortality rates are largely a consequence of late presentation, where most tumours are diagnosed too late due to a lack of screening strategies. We have already conducted molecular studies on a cohort of betel nut-associated oral cancers and have identified potential diagnostic markers and are developing methods of detecting these in saliva and blood. This will greatly aid a more rapid diagnosis of this malignancy and have a direct impact on morbidity and mortality.

Goals

Awareness
Early Detection
Molecular Analysis
Biomarkers
Targeted Therapies

Flagship Projects

BICRAA
BEAT BETEL

Nasopharyngeal Cancer

As a joint effort of most founding members we have recently submitted a publication identifying a novel therapeutic target for nasopharyngeal cancer. In many countries where NPC is a significant problem there is a lack of access to effective treatment options, such as radiotherapy. For example, in some areas of Indonesia, patients diagnosed with MPC will wait months on waiting lists before they are appropriately treated, enabling their cancers to progress to stages, which are either not treatable or limited to palliative measures only. Our goal is to provide both the expertise of identifying this therapeutic target as well as the therapy itself to these areas in order to provide options when others are unavailable or failing. 

We are developing an exchange programme for local doctors to learn how to identify this target in centres of excellence and to establish this technology with the help of AGA-ENT, locally. This is planned in the form of workshops in 2020 as a pilot project to be fully rolled out in 2021. 

Our new article will be available on this website as soon as it is published by the journal.

Goals

Awareness
Early Detection
Molecular Analysis
Biomarkers
Targeted Therapies

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Donation Details

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info@aga-ent.org

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